Pharmacokinetics of aztreonam in patients with various degrees of renal dysfunction
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چکیده
منابع مشابه
Cefsulodin pharmacokinetics in patients with various degrees of renal function.
The pharmacokinetics of cefsulodin were characterized in 19 patients with different degrees of renal function after a single 500-mg, 30-min intravenous infusion. Six subjects had a creatinine clearance (Clcr) of greater than 100 ml min-1 (group I), eight had a Clcr of between 12 and 42 ml min-1 (group II), and five had a Clcr of less than 10 ml min-1 (group III). Nine plasma and four urine samp...
متن کاملClinafloxacin pharmacokinetics in subjects with various degrees of renal function.
As the primary route for elimination of clinafloxacin is renal clearance (CL(R)) of unchanged drug, studies were conducted to determine the pharmacokinetic profile of clinafloxacin following administration to young and elderly subjects, subjects with various degrees of renal function, and subjects requiring dialysis. These were open-label studies in which subjects received single oral clinaflox...
متن کاملPharmacokinetics of meropenem in patients with various degrees of renal function, including patients with end-stage renal disease.
The pharmacokinetics of meropenem were studied after intravenous infusion in 13 patients grouped according to the impairment of their renal function. Creatinine clearance (CLCR) was greater than 50, 50 to 30, and less than 30 ml/min in groups I, II, and III, respectively. Two other groups, groups IV and V, each comprising four patients with end-stage renal disease (CLCR, < 5 ml/min), were also ...
متن کاملPharmacokinetics of intravenously administered ciprofloxacin in patients with various degrees of renal function.
We examined the pharmacokinetic behavior of 200 mg of ciprofloxacin administered intravenously to 32 volunteers whose renal function as measured by creatinine clearance ranged from 0 to 8.99 liters/h per 1.73 m2. Serum clearances (mean +/- standard deviation) were 26.8 +/- 5.7 and 15.4 +/- 4.3 liters/h per 1.73 m2 in normal and anephric volunteers, respectively. The half-life (mean +/- standard...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1983
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.24.2.252